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Glossary of Terms

Your complete guide to weight loss, Ozempic Face, and GLP-1 medication terminology

AMPK (AMP-Activated Protein Kinase)

An enzyme that plays a key role in cellular energy homeostasis. Activated by exercise and certain supplements like berberine.

Berberine

A natural plant compound often called 'Nature's Ozempic' that activates AMPK enzyme and helps regulate blood sugar and metabolism.

BMI (Body Mass Index)

A measure of body fat based on height and weight. GLP-1 medications are typically prescribed for BMI ≥30 or ≥27 with comorbidities.

Collagen

The most abundant protein in your body, providing structure and elasticity to skin, bones, and connective tissues. Collagen loss contributes to aging and Ozempic Face.

Facial Fat Pads

Specialized fat deposits in the face that provide volume and youthful contours. Rapid weight loss depletes these, causing Ozempic Face.

GLP-1 (Glucagon-Like Peptide-1)

A hormone naturally produced in the intestines that slows digestion, suppresses appetite, and helps regulate blood sugar. GLP-1 medications mimic this hormone.

Glucomannan

A natural dietary fiber from konjac root that expands in the stomach, creating fullness similar to GLP-1 drugs.

Half-Life

The time it takes for half of a drug to be eliminated from the body. Ozempic has a 7-day half-life.

Hydrolyzed Collagen

Collagen broken down into smaller peptides for better absorption. The preferred form for supplements.

Intermittent Fasting

An eating pattern that cycles between periods of fasting and eating. Can mimic some appetite-suppressing effects of GLP-1 medications.

Metabolic Adaptation

The body's response to weight loss where metabolism slows down to conserve energy. Can make weight maintenance difficult after stopping GLP-1 medications.

Off-Label Use

Prescribing a medication for purposes other than its FDA-approved indication. Ozempic (approved for diabetes) is often prescribed off-label for weight loss.

Ozempic Face

A colloquial term describing the gaunt, aged facial appearance that can result from rapid weight loss, particularly associated with GLP-1 medications. Characterized by sunken cheeks, increased wrinkles, and sagging skin.

Progressive Overload

Gradually increasing weight, reps, or intensity in strength training to continue building muscle and preventing Ozempic Face.

Rebound Weight Gain

The tendency to regain lost weight (often rapidly) after stopping a weight loss medication or diet. 60-70% of people experience this after stopping GLP-1 drugs.

Retinol

A vitamin A derivative and the gold standard for stimulating collagen production and preventing premature aging.

Semaglutide

The active ingredient in Ozempic and Wegovy. A GLP-1 receptor agonist that mimics the natural GLP-1 hormone.

Skin Elasticity

The skin's ability to stretch and return to its original shape. Decreases with age and rapid weight loss, contributing to sagging.

Tirzepatide

The active ingredient in Mounjaro and Zepbound. A dual GIP/GLP-1 receptor agonist that works on two different hormonal pathways.

Type I Collagen

The most abundant type of collagen in skin (90%). Essential for maintaining skin firmness during weight loss.

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